Well first, let’s explain what puts you most at risk for HIV transmission and why you should consider taking PrEP in the first place – regardless of sexual orientation. So, does PrEP work differently for tops and bottoms? But, you may be wondering if PrEP could affect you differently or be more or less effective depending on if you are a top, bottom, or vers.įor instance, many tops assume they do not need to take PrEP since they are at a lower risk of contracting HIV than a bottom – since they are not penetrated. PrEP is designed to help protect any person – regardless of sexual orientation – from HIV transmission. While some people are at more risk than others due to lifestyle choices or other practices, there is a common misconception that your risk of HIV transmission is higher or lower depending on your sexual orientation or preferred sexual position. It is important that everyone takes the proper precautions to protect themselves from HIV transmission. However, only 35% of gay and bisexual males who were at high-risk of HIV transmission were taking the medication. According to a recent study, the number of gay and bisexual males taking PrEP increased by 500% from 2014 to 2017. Nearly 70% of people living with HIV are homosexual and bisexual men – and thankfully the use of PrEP for HIV prevention is increasing among this group.